March 28-29 2018

San Diego, CA

 

Speakers

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Jeffrey Miller
Professor of Medicine
University of Minnesota

Dr. Miller is currently a Professor of Medicine at the University of Minnesota. He is the Deputy Director of the University of Minnesota Masonic Comprehensive Cancer Center. He has more than 20 years of experience studying the biology of NK cells and other immune effector cells and their use in clinical immunotherapy with over 170 peer-reviewed publications. He is a member of numerous societies such as the American Society of Hematology, the American Association of Immunologists, a member of the American Society of Clinical Investigation since 1999. He serves on the editorial board for Blood and is a reviewer for a number of journals and NIH grants.

Day One

Wednesday March 28th, 2018

16.40 | Novel Strategies to Activate NK Cells for Cancer Therapy

11.40 | Panel Discussion: Evaluate The Challenges Limiting NK Cell Efficacy In Clinical Trials

Wilfred Germeraad
Chief Scientific Officer, Chief Operating Officer & Co-Founder
Cimaas

Wilfred Germeraad obtained a PhD in Immunology from Kyoto University, Japan in 1994. Later he worked for Crucell in the Netherlands as a teamleader of the Dendritic Cell program. Since 2003, he is in Maastricht where together with Gerard Bos he focuses on Immunotherapy for Cancer. As Associate Professor, he is responsible for the development of dendritic cells vaccines and developing natural killer cells for immune reconstitution after/with bone marrow transplantation. In 2015, they founded CiMaas, a startup company aiming to develop cellular immunotherapy for cancer. The company has moved into a new facility in which it can produce GMP grade immune cells for testing in clinical trials for various types of cancer.

Day Two

Thursday March 29th, 2018

09.40 | Allogeneic Natural Killer cell activity in cancer immunotherapy is enhanced by monoclonal antibodies

Katy Rezvani
Chief, Section of Cellular Therapy at Department of Stem Cell Transplantation and Cellular Therapy
MD Anderson Cancer Center

Dr. Katy Rezvani was recruited to MD Anderson in 2012 as Professor of Medicine, Director of Translational Research and Medical Director of the GMP Facility. She was appointed Chief of the Section for Cellular Therapy in the Department of Stem Cell Transplantation in 2017. She is the Principal Investigator on numerous grants and trials. Dr. Rezvani is Specialty Chief Editor for the section of Cancer Immunity and Immunotherapy for Frontiers in Immunology and an Associate Editor for Cytotherapy.  She has over 150 peer-reviewed publications related to Immunotherapy, Cellular Therapy and Hematology/Oncology and hematopoietic transplantation. She is on the Center for International Blood and Marrow Transplant (CIBMTR) clinical trials advisory committee, a member of the BMT CTN Cell and Gene Therapy and is on the organizing committees of the International Society of Cellular Therapy meeting and the Society for Natural Immunity NK 2018 meeting.

Day One

Wednesday March 28th, 2018

09.40 | Off-the-shelf CAR-engineered cord blood-derived NK cells for the treatment of cancer- the first-in-human trial

Michael Caligiuri
Director of the Comprehensive Cancer Center CEO, James Cancer Hospital and Solove Research Institute
Ohio State University

Michael A. Caligiuri, MD, is director of The Ohio State University Comprehensive Cancer Center (since 2004), CEO of Ohio State’s James Cancer Hospital and Solove Research Institute (since 2008), and holds the Nationwide Enterprise Foundation Chair in Cancer Research. He also is a professor in the Department of Internal Medicine and the Department of Cancer Biology and Genetics in Ohio State’s College of Medicine.  Dr. Caligiuri is a physician – scientist whose clinical work is focused in leukemia and lymphoma.

Day One

Wednesday March 28th, 2018

13.55 | NK Fc Bridged Cellular Cytotoxicity - Applications in Cancer

Bob Valamehr
Vice President, Cancer Immunotherapy and Reprogramming Biology
Fate Therapeutics

Bob Valamehr is the Vice President of Cancer Immunotherapy at Fate Therapeutics, overseeing the company’s immuno-oncology and pluripotent stem cell programs, including efforts to develop novel pluripotent cell strategies to create “off-the-shelf” cell-based cancer immunotherapeutics.  Previously, Dr. Valamehr has played key scientific roles at Amgen and at the Broad Stem Cell Research Center developing ways to modulate stem cell fate and better understand cellular signaling pathways associated with cancer.  He has co-authored studies related to stem cell biology, oncology and materials science.  Dr. Valamehr received his PhD from the Department of Molecular and Medical Pharmacology at UCLA and his MBA from Pepperdine University.

Day One

Wednesday March 28th, 2018

11.40 | Panel Discussion: Evaluate The Challenges Limiting NK Cell Efficacy In Clinical Trials

Day Two

Thursday March 29th, 2018

09.10 | Development of FT516: Cornerstone Approach for Off-the-Shelf NK Cell Cancer Immunotherapy

Karl-Johan Malmberg
Professor of Immunology
University of Oslo

Karl-Johan Malmberg is a Hematologist and Professor of Immunology at the University of Oslo, Norway and a Visiting Professor in Cell-Based Cancer Immunotherapy at the Karolinska Institute, Stockholm, Sweden. The Malmberg lab focuses on 1) basic questions concerning NK cell repertoire formation and regulation of effector cell function and 2) translational questions of how NK cells may be function-enabled for anti-cancer activity. The long-term goal of the laboratory is to advance our fundamental understanding of NK cell development and function, and use this progress to design new immunotherapeutic approaches and clinical trials for patients with cancer.

Day One

Wednesday March 28th, 2018

09.10 | How NK cells remember their education - Building functional potential through inhibition

Joachim Koch
Professor of Biochemistry Goethe-University Frankfurt and Research Program Head
Affimed

Prof. Dr. Joachim Koch joined Affimed as Research Program Head in 2016. He is responsible for managing the Company’s joint projects with academic and industrial partners, focusing on the development of novel immune cell engagers and NK cell-based therapeutics. Prior to Affimed, Joachim led the Immunobiology of Natural Killer Cells group, a research group focusing on NK cell tumor immunosurveillance, at the Institute of Tumor Biology and Experimental Therapy (Georg-Speyer-Haus), Frankfurt a. M., and University of Mainz Medical Center. A biologist trained at University of Cologne and Harvard Medical School, Joachim holds a Ph.D. from the University of Heidelberg. Following his Habilitation on viral immune evasion from MHC class I antigen presentation at Goethe-University Frankfurt and at LUMC Leiden, Joachim was granted a Professorship in Biochemistry at Goethe-University Frankfurt.

Day One

Wednesday March 28th, 2018

15.40 | NK Cell-Induced Immunity by Tetravalent Bispecific Immuno-Engagers in Patients Suffering from Hematologic Malignancies

Mark Lowdell
Professor, Cell and Tissue Therapy
University College London

Professor Mark Lowdell PhD FRCPath FRSB is the Professor of Cell & Tissue Therapy at University College London and Director of the Centre for Cell, Gene & Tissue Therapeutics / Honorary Consultant Immunologist at Royal Free Hospital London. He is a qualified diagnostic immunopathologist as well as holding MHRA Qualified Person status for the release of ATMPs for clinical trials and is the current Vice President (Europe & Middle East) of the International Society for Cell Therapy. He has over 20 years’ experience in adoptive immunotherapy of cancer and has focussed on the role of the innate immune responses; especially the role of natural killer (NK) cells.  

Day Two

Thursday March 29th, 2018

12.10 | Priming Human NK cells to Kill NK-Resistant Tumors in The Absence of IL-2

Sang Hoon Paik
General Manager / Head of Process Unit
Greencross

Sang Hoon Paik had worked in pharmaceutical company research institute for more than 22 years, currently he is a General Manager of Cell Therapy Research Center in Green Cross LabCell (GCLC) Corp. He got a Ph.D. degree in Biotechnology, and developed therapeutic biologics by cell culture technology against blood borne diseases and genetic disorder. Based on long term experience of cell culture biotechnology, he started to develop in NK cell therapy for cancer treatment. By developing NK cell therapeutics, his research area extends from process development to commercial scale production using bioreactor. He has conducted the world first clinical trial using random donor derived expanded NK cell and few more clinical trials in hepatocellular carcinoma, acute leukemia and neuroblastoma with or without lymphodepletion. Currently this NK cell program goes on phase IIa against HCC.

Day Two

Thursday March 29th, 2018

10.10 | Process Development and Scale Up for NK Cell by Using Bioreactor

Nicholas Huntington
Molecular Immunology Laboratory Head
Walter and Eliza Hall Institute of Medical Research

A/Prof. Huntington is head the Immunotherapy Lab at the Walter and Eliza Hall Institute of Medical Research. He is an international leader on natural killer (NK) biology and his most notably contributions include; regulatory mechanisms of IL-15 signaling in NK cells, identification of human and murine NK cell differentiation pathways, novel xenograft models to study human NK cell biology and identification of multiple checkpoint in NK cell activation and tumor immunity. A/Prof. Huntington leads a research program aimed at deciphering the regulatory networks that control NK cell development and homeostasis and a drug discovery program using cutting-edge in vivo screens for novel checkpoints in NK cell activation for targeting in cancer immunotherapy.

Day One

Wednesday March 28th, 2018

12.25 | Identification and Drugging NK Cell Checkpoints in Cancer

11.40 | Panel Discussion: Evaluate The Challenges Limiting NK Cell Efficacy In Clinical Trials

Jan Spanholtz
Chief Scientific Officer and Research and Development Manager
Glycostem Therapeutics

Dr. Jan Spanholtz initiated Glycostem's research in the start-up phase in 2007 and is currently Chief Scientific Officer (CSO) of Glycostem. Dr. Jan Spanholtz has more than 15 years of expertise in research on stem cell biology and immunology at universities and within biotech companies. He is author of various peer-reviewed research articles and inventor of Glycostem's proprietary technology platform to generate oNKord® from umbilical cord blood stem cells. For Glycostem, he has set-up and managed several national and international collaborations and spearheaded clinical translational of Glycostem's NK-cell product, oNKord®. He has developed the core IP strategy for Glycostem as inventor of feeder cell free NK-cell culture method from cord blood stem cells, synthetic culture medium for NK-cells and has was also part of several other patent applications in the stem cell field.

Workshop A

Tuesday July 25th, 2017

09.00 | Investigating the Regulatory Checkpoints that Need to be met in NK Cell Therapies

Day Two

Thursday March 29th, 2018

12.40 | oNKord® - Next generation products – From proven safety to established efficacy

Dan Kaufman
Professor of Medicine & Director of Cell Therapy
University of California

Dr. Kaufman moved to UCSD is a Professor in Department of Medicine, Division of Regenerative Medicine and Director of the Cell Therapy program at UCSD. This position includes development of a GMP lab to translate more cell-based therapy into clinical trials. Dr. Kaufman does clinical work in hematology/BMT. His research focuses on use of human pluripotent stem cells to study development of hematopoietic stem/progenitor cells, lymphocytes, and other mesodermal lineages. In particular, his studies have developed efficient means to produce natural killer cells from human ES cells and iPSCs suitable for new clinical applications to treat relapsed/refractory cancers- both hematologic malignancies and solid tumors. Current studies aim to translate use of these cells into clinical therapies and to engineer these NK cells with novel receptors to improve killing of cancer cells.

Day One

Wednesday March 28th, 2018

10.10 | Development of novel NK cell-specific chimeric antigen receptors to improve anti-tumor activity.

Sandip Patel
Assistant Professor,, Medical Oncology/Hematology
UC San Diego Moores Cancer Center

Sandip Patel, MD, is a board-certified medical oncologist who specializes in cancer immunotherapy and early phase clinical trials involving immunotherapy across all types of cancer. Dr. Patel is focused on developing personalized therapies that stimulate a patient’s immune system to attack their specific tumor. He believes in offering these promising immunotherapeutics across all tumor types. As an assistant professor in the Department of Medicine, Dr. Patel instructs medical students, residents and fellows. His research focuses on developing biomarkers for personalized immunotherapy to better determine which combination of therapies works best for each individual.

Day One

Wednesday March 28th, 2018

14.25 | Panel Discussion: The Future Potential of NK cells In Combination Therapies

Robin Parihar
Assistant Professor, Center for Cell and Gene Therapy
Baylor College of Medicine

I am a pediatric oncologist with an interest in caring for children with solid tumors. I have an active research lab interested in stimulating the immune system to fight solid tumors. My lab investigates the role of a specific type of immune cell called the natural killer (NK) cell in the control of cancer. My current research projects aim to enhance NK cell function in order to target the tumor microenvironment, essentially getting rid of the accessory cells that help a tumor resist standard therapies. I am currently working on introducing the enhanced NK cells as therapy for children with advanced cancers. In addition, we are using our established lab models to better understand how the tumor microenvironment suppresses the immune system, in order to develop new approaches to overcome this inhibition and improve immune-based therapies for pediatric cancers.

Workshop B

Tuesday July 25th, 2017

13.00 | An Exploration of the Tumor Microenvironment To Prevent Tumor Escape from NK Cell Cytotoxic Activity

Day Two

Thursday March 29th, 2018

14.10 | The Role of NK Cells Targeting Suppressive Components of the Tumor Immune Microenvironment in the Treatment of Refractory Solid Tumors

Eugene Zhukovsky
Chief Scientific Officer
Biomunex Pharmaceuticals

Dr. Zhukovsky has over two decades of professional experience in the field of biotherapeutics research and development, in particular, optimized antibody therapeutics for oncology. He joined Biomunex Pharmaceuticals in January 2015 as Chief Scientific Officer. Previously, he served as the CSO of Affimed Therapeutics. Prior to that Dr. Zhukovsky was a Senior Research Fellow at Boehringer Ingelheim Pharmaceuticals, Inc., an Associate Director at Xencor, Inc., a Senior Scientist at Lynx Therapeutics, and a Scientist at Neurex Corporation and a postdoc at Genentech, Inc. He received a PhD in biochemistry from Brandeis University and an MS degree in bioorganic chemistry at St. Petersburg's University.

Day One

Wednesday March 28th, 2018

14.25 | Panel Discussion: The Future Potential of NK cells In Combination Therapies

Katharine Hsu
Attending Physician and Member, Bone Marrow Transplantation
Memorial Sloan Kettering Cancer Center

I am a hematologist and medical oncologist specializing in natural killer (NK) cell biology, stem cell transplantation, and adoptive cell immunotherapy. The major focus of my research is to determine how to use cutting-edge information about NK cells, their genetics and biology, to improve outcomes in the treatment of hematologic malignancies, particularly those treated with stem cell transplantation.  Specifically, my laboratory focuses on the molecular interactions between KIR and their HLA ligands that contribute to NK education and inhibition both in vitro and in vivo. Identification of the relative strengths of these interactions and how they affect innate immune clearance of leukemia and viruses will lead to more sophisticated genetic algorithms in donor selection for stem cell transplantation.  More broadly applied, a deeper understanding of KIR-HLA control of NK function will inform interventions that can release higher NK activity against viral infection and malignancy.

Day One

Wednesday March 28th, 2018

16.10 | Exploring the Importance of NK Phenotype to Ensure Best Clinical Results

Raymond Urbanski
Chief Medical Officer
GT Biopharma

Day One

Wednesday March 28th, 2018

14.25 | Panel Discussion: The Future Potential of NK cells In Combination Therapies

Steve Doberstein
Chief Scientific Office and Senior Vice President of Research
Nektar Therapeutics

Steve Doberstein joined Nektar in January 2010 as Senior Vice President and Chief Scientific Officer to lead discovery research at Nektar. Dr. Doberstein brings over 20 years of experience in biotechnology research and development to the company. Prior to joining Nektar, Dr. Doberstein served as Vice President of Research at XOMA, Five Prime Therapeutics, and Xencor, and held a variety of senior positions at Exelixis. His experience spans small molecule, protein therapeutics, and monoclonal antibody discovery and development in therapeutic areas including oncology, neuroscience, inflammation, immunology, and metabolic diseases. Dr. Doberstein also serves as the Chairman of the Board of Nektar India.

Day Two

Thursday March 29th, 2018

11.40 | NK Cell Expansion and Activation through Engineered Cytokines