July 25-27 2017

San Diego, CA

 

Workshop A
Tuesday July 25th, 2017

09.00 - 12.00
NK Cell Line Anti-Cancer Therapy: A Potentially Effective and Safe Alternative
Workshop Leader: Torsten Tonn, Professor for Transfusion Medicine, Medical Faculty Carl-Gustav-Carus, Technische Universität Dresden


In this workshop learn how:

  • NK cell line NK-92 exhibits cytotoxicity against a wide range of cancer cell lines and primary cancer cells, including many blood cancers and several solid tumors
  • Discuss how mode of action is predominantly by granule exocytosis via activation of activating receptors, especially NKp30 and DNAM-1
  • Debate on NK-92 lacks inhibitory (KIR) receptors
  • We have completed a phase I trial of irradiated NK-92 in patients with refractory blood cancers relapsing after stem cell transplant and showed safety with minimal side-effects and evidence of efficacy including a patient with prolonged, unmaintained remission
  • NK-92 engineered to express CD16 can engage in ADCC
  • Hear how CD16+ NK-92 in conjunction with specific monoclonal antibodies shows enhanced survival in xenogeneic models of different malignancies leading to the development of clinical trial protocols
  • CARs with specific targeting that result in tumor control
  • CARs targeting novel antigens
  • Attempts at modification of NK cells from different sources
  • NK product development

Torsten Tonn, Professor for Transfusion Medicine, Medical Faculty Carl-Gustav-Carus, Technische Universität Dresden

Torsten Tonn

Workshop B
Tuesday July 25th, 2017

13.00 - 16.00
Applications of a Quantitative Imaging Tool Box in Evaluating a CAR Immune Synapse and Contributing to Rational CAR Design
Workshop Leader: Malini Mukherjee, Instructor, Center for Human Immunobiology Cell & , Gene Therapy, Baylor College of Medicine


There are many tools that can be utilizied to quantitatively measure cell killing and this workshop will outline the following:

  • What is the immune synapse?
  • What do we know about the CAR immune synapse?
  • What are the tool box components and how do they evaluate a CAR cytotoxic function above and beyond traditional cytotoxicity assays?
  • Examples of toolbox based mechanistic understanding of CARs
  • Future applications of toolbox in the rational design of CARs

Malini Mukherjee, Instructor, Center for Human Immunobiology Cell & , Gene Therapy, Baylor College of Medicine

Malini Mukerjee.jpeg