Digital Day Two
Jam packed with unpublished clinical data, group discussion forums, and new updates in solid tumors and infectious disease, join with your team so you don’t miss a thing!
Showcasing updates from Genentech, Century Therapeutics, Artiva Biotherapeutics and Kuur Therapeutics, join day 2 to get up to speed on …
- Clinical development of human placental hematopoietic stem cell derived NK cells for the treatment of COVID-19
- Unpublished clinical data shared from Acepodia and Jeffrey Miller, University of Minnesota focused on off-the-shelf strategies to increase activity and specificity
- The role of CAR-NKT cells as a solution to the solid tumor challenge
- Combination approaches with monoclonal antibodies to support the efficacy and potency of NK cell therapy
And much more!
Key speakers include:
9:00 - 5:15 EDT | 6:00 - 12:15 PDT - All times are shown in EDT
9:00 am Coffee & Networking
9:00 am Coffee & Networking
9:25 am Chair’s Opening Remarks
9:25 am Chair’s Opening Remarks
Keynote Clinical Data
Keynote Clinical Data
9:30 am Allogeneic Off-the-Shelf NK Cell Therapy Using Antibody Cell Conjugation (ACC)
9:30 am Allogeneic Off-the-Shelf NK Cell Therapy Using Antibody Cell Conjugation (ACC)
Synopsis
• Introduction of Acepodia’s oNK and ACC platforms
• Preclinical studies of anti-HER2 conjugated oNK cells (ACE1702)
• Clinical trials of ACE1702 in the US
Unpublished Data
9:55 am NK Cell Therapeutics: Off-the-shelf Strategies to Increase Activity and Specificity
9:55 am NK Cell Therapeutics: Off-the-shelf Strategies to Increase Activity and Specificity
Synopsis
• Understand the differentiation of NK cells from induced pluripotent stem cells (iNK)
• Review the early clinical safety and activity of iNK
• Outline the clinical power of immune engagement with IL-15 containing TriKEs
Unpublished Data
10:20 am Allogeneic Natural Killer Cell Therapy for Patients with Relapsed/Refractory Lymphoid Malignancies: Novel Strategy Using Nicotinamide Ex Vivo Expansion
10:20 am Allogeneic Natural Killer Cell Therapy for Patients with Relapsed/Refractory Lymphoid Malignancies: Novel Strategy Using Nicotinamide Ex Vivo Expansion
Synopsis
• Review novel therapeutic product using allogeneic NK cells expanded with nicotinamide and IL-15 ex vivo (GDA-201), which is characterized by potent cytotoxicity, cytokine production, resistance to oxidative stress and enhanced ability to persist in vivo and traffic to tumor sites.
• In the first in human Phase 1 study in patients with relapsed/refractory non-Hodgkin lymphoma and multiple myeloma we examined GDA-201 Maximum Tolerated Dose and safety profile with no evidence of immune mediated adverse events
• Discuss the demonstration of substantial clinical efficacy and durable remissions in patients with follicular lymphoma and DLBCL with novel correlative data
Unpublished Data
10:45 am CAR-NK Cells from Engineered Pluripotent Stem Cells; Off-The-Shelf Therapeutics for All Patients
10:45 am CAR-NK Cells from Engineered Pluripotent Stem Cells; Off-The-Shelf Therapeutics for All Patients
Synopsis
- HebeCell’s robust proprietary scalable 3D-platform technology for pluripotent stem cell (PSC) expansion and feeder-free NK cell differentiation: superior scalability and consistency compared to traditional approaches
- Master PSC-CAR cell bank targeting indication-specific antigens: inexhaustible cell sources for the manufacture of truly off-the-shelf and cost-effective CAR-NK cells for all patients of cancer, infectious and autoimmune diseases
- Collaboration with world renowned scientists and alliance with leading immune cell therapy companies: co-develop PSC-CAR-NKs targeting a variety of hematopoietic and solid malignancies to accelerate early clinical success
11:15 am Refreshment Break
11:15 am Refreshment Break
2:00 pm Speaker Break Out Discussions
2:00 pm Speaker Break Out Discussions
Synopsis
Our speakers of the previous session will join the speaker break out room where you can meet them, ask any further questions you might have and continue the conversation
2:15 pm Refreshment Break
2:15 pm Refreshment Break
2:45 pm Round Table Discussion Session
2:45 pm Round Table Discussion Session
Synopsis
1. NK Therapy for Infectious Disease
• Review the possibility of treating viral infections with NK-cell therapy
• Discuss the clinical need and market opportunity
• Identify which viral infections should be targeted
• Review the NK-cell engineering strategies that are needed to target viral infections
Elie Haddad, Head, Research Axis, Immune Disorders & Cancers, CHU Sainte-Justine
2. Enhance Clinical Efficacy Through Combination Approaches
• Discuss the possibility of combining current NK cell-based immunotherapies with monoclonal antibodies, different types of engagers, small molecules, and/or established drugs which may offer additional impact of NK cells in therapeutic settings
• Outline the pros and cons, challenges and opportunities, lessons learned and experiences to date
Hans-Gustaf Ljunggren, Professor, Group Leader, Karolinska Institute
3. What are the Requirements for Successful Natural Killer Cell Therapy? Studies from Cancer patients and Those in Humanized Mice
• Discuss different NK cell therapeutics in the market and compare and contrast the advantages and disadvantages of each platform
• Delineate the requirements for successful NK cell therapy
• Consider the ability to kill tumor cells at different stages of differentiation and their ability to successfully target tumor cells without becoming inactivated by the tumor
• Review combined therapies with NK cell therapy such as chemotherapy, radiation, oncolytic virus therapy, CAR-T and CAR-NK therapy and CD8+ T cell therapy
Anahid Jewett, Professor & Director, Tumor Immunology Laboratory, UCLA
Understanding NK Cell Interaction in the TME to Tackle Solid Tumors
Understanding NK Cell Interaction in the TME to Tackle Solid Tumors
3:30 pm Exploring the Network of Cellular Interactions of NK Cells in the Tumor Microenvironment
3:30 pm Exploring the Network of Cellular Interactions of NK Cells in the Tumor Microenvironment
Synopsis
• Describe NK cell : tumor cell : NK cell interactions and the definition of “NK resistance”
• Review regulatory T cells and regulatory NK cells in the TME
• Potentiation of impaired NK function in the TME to overcome hypoxia-induced suppression
3:55 pm CAR-NKT Cells: A Solution to the Solid Tumor Challenge
3:55 pm CAR-NKT Cells: A Solution to the Solid Tumor Challenge
Synopsis
• Examine the biology of NKT cells
• Share approaches to engineer NKT cells to attack solid tumors
• Describe preclinical and early clinical proof of concept
The Role of NK in Viral Infection
The Role of NK in Viral Infection
4:20 pm Preclinical and Clinical Development of Human Placental Hematopoietic Stem Cell Derived NK Cells (CYNK001) for the Treatment of COVID-19
4:20 pm Preclinical and Clinical Development of Human Placental Hematopoietic Stem Cell Derived NK Cells (CYNK001) for the Treatment of COVID-19
Synopsis
• Celularity has developed a novel proprietary GMP procedure that enables the scalable production of an off-the-shelf, allogeneic NK cell therapy (CYNK-001)
• Combining pathogenic mechanism of coronavirus, existing and validated research results, we hypothesize adoptive CYNK001 therapy may provide the antiviral activities thereby serve as effective solutions for COVID-19 patients
• Discuss the initial findings from our clinical investigation and continuous development of CYNK-001 for infectious diseases
4:45 pm NK Cell Immunotherapy as a HIV Cure Strategy and in the Context of Non-Aids-Defining Cancer Treatments
4:45 pm NK Cell Immunotherapy as a HIV Cure Strategy and in the Context of Non-Aids-Defining Cancer Treatments
Synopsis
• Human NK cells mediate adaptive immune responses to virally encoded antigens, including HIV-Env, in humanized mice and human volunteers
• NK cells lower HIV viral titers in CTL depleted HIV-challenged humanized mice
• NK cell adoptive transfers into syngeneic HIV-naive humanize mice lower HIV viral titers upon experimentally HIV challenged