Christian Capitini

Christian Capitini

Company: University of Wisconsin, School of Medicine & Public Health

Job title: Associate Professor


Driving Persistence & Efficacy with NK, Checkpoint & Tumor-Directed Vaccine Combinations 11:00 am

Identifying synergies between mechanisms of action of multiple modalities to rationalize combination strategy for solid tumors in an antigen-specific manner Discussing how combinations can enhance efficacy, providing tumordirected therapy against neuroblastomas in pediatric indications Showing how combinations can reduce NK cell exhaustion post-infusion to enhance therapeutic persistenceRead more

day: Day One Track B AM

Optimizing Virus-Free CRISPR Editing to Integrate Larger, more Complex Payloads 2:00 pm

Discussing the mechanism of action and variants of CRISPR editing Sharing development of CRISPR and base edited innate therapies, highlighting major bottlenecks and advantages such as loci for dual knock in and knock out to simultaneously up and down regulate genes Avoiding off-target CRISPR cuts, minimizing chromosomal instability, evaluating off-target effects, and demonstrating safety of…Read more

day: Next-Generation Engineering Focus Day
day: Pre-Conference Day Track A PM

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