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Pre-Conference Bootcamp

12:30 pm Registration & Networking

12:55 pm Chair’s Opening Remarks

1:00 pm Human NK Cell Differentiation & Migration

  • Emily Mace Assistant Proffesor, Columbia University in the City of New York

Synopsis

  • Exploring the role of cell migration in NK cell development
  • Understanding the regulation of adhesion and cell migration in human NK cells
  • Understanding links between cell migration and lytic function

Examining the Mechanisms of NK Cell-mediated Cytotoxicity

1:30 pm Insights into the Cytotoxic Mechanisms of NK Cells During Serial Killing

Synopsis

  • Highlighting how NK cells switch their killing mechanism from Granzyme to death receptor mediated cytotoxicity during serial killing
  • Deliberating why Granzyme-mediated cytotoxicity is the only mechanism that allows for serial killing
  • Outlining that NK cells become exhausted but don’t die after serial killing
  • Discussing why detachment from target cells is an important step in serial killing and is regulated by the death of the target cell

2:00 pm A New Mechanism of NK-cell Cytotoxicity Against Pre-B ALL Cells

  • Elie Haddad Professor of Paediatrics , University of Montreal

Synopsis

  • Discovering NK cells’ capacity to kill supposedly resistant pre-B ALL cells
  • Outlining mechanisms that cause delayed killing independent of granule exocytosis or the death receptors cytotoxic pathways
  • Discussing how this new mechanism does not require caspase activation or mitochondrial depolarization

2:30 pm Afternoon Refreshments & Networking

2:35 pm

Discovering Alternative Avenues for Cell Therapies

3:15 pm The Sweet Side of Immune Evasion

Synopsis

  • Assessing how aberrant glycosylation is a recognised hallmark of cancer with increased cell surface expression of sialic acid (hypersialylation) and seeing aberrant glycosylation as a common feature
  • Associating hypersialylation with increased risk of disease progression and poor survival in numerous cancers, including Multiple Myeloma. In addition to influencing homing, cell trafficking and drug resistance, hypersialylation enables immune evasion, in part via engagement of sialic acid binding, inhibitory  checkpoint like receptors called Siglecs, which are present on immune cells, such as macrophages, activated T cells and NK cells
  • Reviewing our current understanding of the role of sialylation within the immune microenvironment, including potential strategies to overcome sialylation induced immune evasion, leading to enhancement of both innate and adaptive immune responses

3:45 pm Distinct Effects of Cannabinoids on Differentiated vs. Cancer Stem Cells; Role in Natural Killer Cell Activation

Synopsis

  • Differential underlying mechanisms of NK cell targeting of well-differentiated vs. Poorly differentiated tumors/Cancer Stem Cells
  • Differential effect of Cannabinoids on differentiated vs. Cancer stem cells
  • Effect of Cannabinoids in vivo on patients’ Natural Killer cells and its potential relationship with survival
  • Effect of Cannabinoids on NK cells in vivo in humanized mouse model
  • Potential mechanisms of NK cell activation by Cannabinoids

4:15 pm End of Bootcamp Day