Multiplex Engineering of NK Cells to Resist the Tumor Microenvironment for More Effective Activity & Therefore More Successful Therapies

• Disarming immune suppression by engineering NK cells to resist inhibitory signals
• Overcoming NK cell-intrinsic checkpoints to boost NK metabolism and functional activity
• Combining multiplex base editing and CAR and cytokine engineering to enhance activity to antigen positive and negative tumors

Speakers:

Neil Sheppard

Director of Research Technologies & Innovation at the Center for Cellular Immunotherapies

University of Pennsylvania