Nikolaus Trede

Company: Century Therapeutics

Job title: Senior Vice President & Head of Clinical Development

Seminars:

Optimizing Engineered Stealth Features for Allogeneic Cell Therapies 2:00 pm

Comprehensive allo-evasion engineering addressing both cellular and humoral allo-rejection mechanisms: HLA knock-out to prevent T-cell rejection HLA class I surrogate overexpression and TASR technology to prevent NK cell rejection IdeS to degrade pre-existing or de novo generated antibodies directed to the product Sharing preclinical and clinical insights of this approach in NHL and autoimmune diseaseRead more

day: Day 1 - Track A - PM

Panel Discussion: Evaluating NK Treatment Regiments in Autoimmune Patients to Maximize Treatment Outcomes 10:30 am

Discussing patient treatment regiments and pre-treatment procedures in an autoimmune setting Do the same measures such as lymphodepletion need to be applied to autoimmune patients? What dosing regiment may be most beneficial for autoimmune patients?  Is it feasible to dose autoimmune patients several times?Read more

day: Pre-Conference Focus Day

Evaluating Donor-Derived Versus iPSC-Derived NK Therapies to Understand Advantages & Drawbacks of Each 1:05 pm

Dive into the source of NK cell therapies in this dynamic workshop, where we debate donor-derived versus iPSC-derived NK cells. Uncover the distinct advantages and challenges of each approach, from clinical effectiveness, editing efficiency to scalability. Gain the insights needed to make strategic decisions in sourcing NK cells. Comparing and contrasting different sources of NK cells to understand…Read more

day: Pre-Conference Workshop Day